On the other hands, IFN-α or IFN-γ induces the expression of ACE2 in airway epithelial cells (86) and expression of IFNs is lower in patients with high eosinophil counts (87), suggesting that eosinophil-mediated suppression of IFN production in epithelial cells may be associated with suppression of ACE2 expression and thus COVID-19. The gene discussed is IFNA1; the disease is COVID-19.