In addition, transfection of CDHR3-Y529 into HeLa cells increases eosinophil adhesion and superoxide anion production compared to CDHR3-C529 or negative controls, suggesting a possible role for CDHR3-induced eosinophil activation in the development of asthma exacerbation, especially with the CDHR3 variant. Here, CDHR3 is linked to asthma.