Based on various kinds of infection, Gsdmd-/- display more or less susceptibility to invasion comparing to wild-type mice (92–95). Gsdmd-/- mice are also used in behavioural test, and presented with increased anxiety (96). In experimental autoimmune encephalomyelitis (EAE) mouse model, Gsdmd-/- mice exhibit resistance from death and morbidity (71, 97). Here, GSDMD is linked to experimental autoimmune encephalomyelitis.