IL13 and Stroke: The long-term consequences of prolonged inflammation include dysfunctional or diminished tissue repair, synaptic plasticity, neurogenesis, axonal and dendritic spine regeneration, neural network reorganization, interhemispheric connections, and neuroplasticity (118, 130) In a preclinical study of MCAO mice, peripheral administration of IL-13 was found to induce an anti-inflammatory microglial response, resulting in improved gait and sensorimotor deficits at seven and 14 days post-stroke, respectively (130).