Figure 4C shows the distribution of Ti and Tv of necroptosis gene sets in the sample set of pan-cancer types for SNV classifications based on C>T and C>A. SNV survival analysis revealed significant differences in survival between mutated and non-mutated genes, e.g., mutated and non-mutated genes in BAX in BRCA, and NLRP7 in mesothelioma (MESO) (Supplementary Figure 5). The gene discussed is NLRP7; the disease is cancer.