SFRP1 and rheumatoid arthritis: Through the promotion of SFRP1, it is highly expressed in RA-FLS, so as to observe whether it can inhibit the activation of Wnt/β-catenin and Notch signaling pathway and the occurrence of pyroptosis, whether it can improve the inflammatory microenvironment of joint synovium and alleviate the symptoms of RA, which will be our main research work.