Recent studies have shown that the an increased expression of proteins such as Wnt3a, Wnt5a, and Wnt10a in RA-FLS (Table 1), activates the Wnt signaling pathway and downstream genes, and increases the expression of fibronectin, thereby promoting cell proliferation, migration, and survival, and promotes RA synovial tissue proliferation in the absence of pro-inflammatory factors (24, 25). This evidence concerns the gene WNT5A and rheumatoid arthritis.