Therefore, the inhibition of hypermethylation of SFRP1 by methylation inhibitors is helpful in upregulating the expression of SFRP1, competitively inhibiting the signal transduction of Wnt/β-catenin and Notch, the release of downstream inflammatory cytokines, and NLRP3-mediated cell pyroptosis, thus playing a role in the treatment of RA. This evidence concerns the gene SFRP1 and rheumatoid arthritis.