Notably, Lactobacillus treatment on lupus prone MRL/lpr mice significantly increased the expression of multiple tight junction proteins, including ZO1, Occludin, and Claudin-1, in intestinal epithelial cells, suggesting that certain probiotics may rescue gut permeability detected in SLE patients and restore the normal gut barrier function (176). The gene discussed is TJP1; the disease is systemic lupus erythematosus.