Apart from this similarity, different virus infection pathways owned their unique genes, with STAT1,RSAD2 and IRF9 in the influenza A pathway,IL-2RA,IL-2RB and CD40 in the HTLV-1 infection pathway, HCFC1, MAP3K7, SOCS3, IRF9, HMGN1, and FAS in the herpes simplex infection pathway. This evidence concerns the gene HMGN1 and herpes simplex infectious disease.