41 patients (74%) had ITP, 17 patients (31%) had AIHA and 10 patients (18%) had neutropenia. 36 patients in this group developed splenomegaly (65%) and 8 patients developed a granulomatous disease (14%); a significant correlation was found between an increased proportion of CD21low B cells and CVID associated autoimmune cytopenia; in CVID associated autoimmune cytopenia, T cells display an activated phenotype with an increase of HLA-DR and CD95 expression and a decrease in the naïve T cell numbers. This evidence concerns the gene FAS and common variable immunodeficiency.