CD4 and neoplasm: Based on previous studies (12–15), the conference on TH1 (T helper type 1), TH2 (T helper type 2), TH17 (T helper type 17), Tfh (T follicular helper), and Treg (CD4+ regulatory T) cells as a group of CD4+ TH cells that are independent and have a chain reaction with TILs is very meaningful to avoid tumor immune escape and improve the efficacy of immunotherapy for breast cancer.