RNF122 and viral infectious disease: Similarly, interferon induces expression of RNF122 (128) and RNF125 (129) to ubiquitinate and degrade RIG-I/MDA5, triggers TRIM13 synthesis to degrade MDA5 (147), or promotes RNF5 (168) and MARCH5 (162, 163) expression to degrade MAVS, all leading to inactivation of RNA sensing signaling after viral infection.