IFI16 and cytomegalovirus infection: Human cytomegalovirus (HCMV) infection on human embryonic lung fibroblasts induced viral pUL97-mediated phosphorylation on IFNγ-inducible protein 16 (IFI16), which facilitates the mis-localization of IFI16 into the cytosol to disable its viral DNA sensing ability (58) (Table 1).