One possible mechanism to explain how STING-S366 phosphorylation primes STING for degradation might be mediated by STING deSUMOylation, such that STING-S366 phosphorylation promotes SENP2 recognition at the late stage of viral infection that facilitates STING deSUMOylation, allowing STING ubiquitination to occur for STING degradation (51). The gene discussed is STING1; the disease is viral infectious disease.