Similarly, viral infection also induces binding of the mitochondrial E3 ligase MARCH5 to aggregated and active MAVS, where MARCH5 ubiquitinates K193/K203 (162) or K7/K500 (163) through a K48 linkage for MAVS destruction, serving as a negative feedback mechanism to restrain sustained MAVS activation. The gene discussed is MAVS; the disease is viral infectious disease.