On the contrary, trogocytosis at low ratios of PMN to CLL-B cells opsonized with anti-CD20 mAbs does not induce significant death (11) unless SIRPα is blocked allowing activation of NADPH oxidase and strong killing, as we show here for ratios between 3 and 0.5 PMN to 1 target cell. Here, SIRPA is linked to B-cell chronic lymphocytic leukemia.