In rat model of hepatic fibrosis, it was found that miR-34a was overexpressed, SIRT1 was down-regulated, p53 and ac-p53 were increased, with activated TGF-β1/Smad signal pathway; miR-34a inhibitor and p53 siRNA significantly prevented TGF-β1-induced EMT in hepatocytes, and alleviated the degree of hepatic fibrosis (Song et al., 2019). This evidence concerns the gene SIRT1 and Hepatic fibrosis.