On the contrary, septic rats pretreated with the nutraceutical showed increased gene expression of the antioxidant enzymes GSR and SOD-1 and decreased mRNA levels of the pro-oxidant enzyme NOX-1 in myocardial tissue, pointing that the myocardial beneficial effects are most likely due to reduced oxidative stress, as it has been previously described after supplementation with ω3-PUFAs in experimental models of sepsis (61, 62). This evidence concerns the gene NOX1 and Sepsis.