IGFBP3 and Sepsis: Figure 6A shows that sepsis was also associated with a significant decrease in the mRNA levels of IGF-1 (p < 0.05), MHC-I (p < 0.001) and MHC-IIA (p < 0.01) mRNA levels and with an overexpression of IGFBP-3 (p < 0.05) in gastrocnemius muscle.