As shown in Figure 6A, pretreatment with the nutraceutical partially prevented the sepsis-induced upregulation (p < 0.001) in the mRNA levels of the ubiquitin ligases, atrogin-1 and MuRF1 (p < 0.05 for both) and the autophagy marker LC3b (p < 0.01) in gastrocnemius muscle. Here, TRIM63 is linked to Sepsis.