CD274 and gastric cancer: The trial also reported that the median progression-free survival (PFS) was 1.5 months with pembrolizumab and 4.1 months with paclitaxel, demonstrating that pembrolizumab did not significantly improve OS compared to paclitaxel as second-line therapy for advanced gastric cancer with PD-L1 CPS ≥1 (Shitara et al., 2018).