There is an increasing number of clinical or preclinical research on ADCs in the field of solid cancer with a rough estimate more than 30 ADCs, 15ADCs, 10 ADCs, 10 ADCs, and 5 ADCs in gastrointestinal malignancies, gynecological malignancies, lung cancer, HER2-positive breast cancer and hepatocellular carcinoma, respectively (Ferraro et al., 2021; Martín-Sabroso et al., 2021; Ricciuti et al., 2021; Singh et al., 2021; Murali et al., 2022). Here, ERBB2 is linked to breast cancer.