PKM and hepatocellular carcinoma: For example, Jia et al. demonstrated that the lncRNA LNCAROD induced pyruvate kinase isoenzyme M2 (PKM2) upregulation via sponging miR-145–5p, increased aerobic glycolysis in hepatocellular carcinoma cells, and was eventually involved in tumor malignancy and chemoresistance (Jia et al., 2021).