A study named Open-Label Study of Long Term Evaluation Against LDL-C (OSLER-1) [28] was carried out to assess the long-term impact of evolocumab in an open-label hypercholesterolemia treatment for a duration of five years - the longest period for the use of PCSK9 inhibitor antibodies. The gene discussed is PCSK9; the disease is Hypercholesterolemia.