Strikingly, among genes exclusively mutated at recurrence in hypermutant GBM, a combination of six genes (denoted as Hyper-6: LRP1A, PCNX1, KMT2D, DST, SYNE2 and NEB) was able to successfully identify 100% of hypermutated tumors (Figure 5A). Here, NEB is linked to glioblastoma.