However, comparing with patients without AKI, those with AKI had higher APACHE II (13.90 ± 3.64vs. 20.33 ± 2.73, p ≤ 0.01) and SOFA scores (7.11 ± 1.89 vs. 9.76 ± 3.30, p ≤ 0.01) as well as higher serum creatinine, C-creative protein, and PCT levels. The gene discussed is BTBD8; the disease is acute kidney injury.