C1QTNF3 and obesity due to melanocortin 4 receptor deficiency: Because CTRP3 deficiency is linked to increased oxidative stress and cell death in cardiomyocytes, the influence of melatonin on CTRP3 secretion into the circulatory system and increased cardiac CTRP3 expression may help to prevent obesity in patients with heart failure with preserved ejection fraction (445).