Previously, Semba et al. first revealed a negative association between α-Klotho and total CVD among 1,023 members of the general population in Italy (16); intriguingly, they defined the CVD outcome as participants with any CHF, CHD, stroke, or peripheral artery disease, but they did not report a correlation between α-Klotho and a single disease. The gene discussed is KL; the disease is stroke disorder.