In OSCC, a number of lncRNAs, such as MALAT1 [28, 29], UCA1 [30, 31], FTH1P3 [32], PDIA3F, GTF2IRD2P1 [33], FOXC1, and FOXCUT [34] have been functionally identified, but compared to other cancers, the overall biological role and clinical significance of lncRNAs in OSCC remains largely unknown. The gene discussed is MALAT1; the disease is cancer.