CASP1 and acute kidney injury: The renal tubules of wild-type mice with iohexol-induced AKI were severely damaged, and their serum creatinine levels were significantly higher than that of nlrp3−/− and casp1−/− mice that indicate the activation of NLRP3 inflammasome in iohexol-induced-AKI mice and alleviation of iohexol-induced kidney injury and apoptosis in nlrp3−/− and casp1−/− mice [9].