TGFB1 and Alzheimer disease: As can be seen from Figure 9, the six targets of IL1B, MAPK8, MMP2, RELA, STAT3, and TGFB1 are not only significantly related to Aβ and Tau but also related to age, so we speculate that these six targets are the core targets of CR for the prevention and treatment of AD (Table 3).