HIF1A and Chagas disease: Various diseases may share the exact mechanism of AD, such as NAFLD, Hepatitis B, Chagas disease, Tuberculosis, etc. Among the significant enrichment pathways, the key pathways were the HIF-1 signaling pathway, the PI3K-Akt signaling pathway, the Toll-like receptor signaling pathway, the NOD-like receptor signaling pathway, and the MAPK signaling pathway.