HIF1A and Alzheimer disease: In the following Figure 7A, we showed the enrichment of the top 15 signaling pathways, which are the HIF-1 signaling pathway, the PI3K-Akt signaling pathway, the Toll-like receptor signaling pathway, the NOD-like receptor signaling pathway, the MAPK signaling pathway, the AMPK signaling pathway, and other pathways indicated that CR plays a role in the prevention and treatment of AD through multiple ways.