Rg1 and Re exhibited similar anti-aging effects as TGGR in Drosophila. Consistent with other studies, Rg1 and Re are the major components of Panax ginseng, which prolongs the lifespan of C. elegans (Wang et al., 2021), and Rg1 prevents cognitive impairment and hippocampal senescence in a rat model of aging (Zhou et al., 2020). The gene discussed is PPP1R3A; the disease is Cognitive impairment.