Ubiquitinylated and misfolded proteins are aggregated in PD, which includes genes encoding regulatory molecules, such as PTEN-induced kinase 1 (PINK1), Parkin, and FBX07, which has provided an opportunity to dissect the molecular basis of ubiquitin signaling in PD pathomechanism and develop novel therapeutic strategies in PD(Walden and Muqit, 2017). Here, PRKN is linked to Parkinson disease.