TARDBP and frontotemporal dementia: For example, TAR DNA binding protein of 43 kDa (TDP-43) is involved in apoptosis, cell division, and axonal transport through regulation of transcription, alternative splicing, and mRNA stability in frontotemporal dementia (FTD), AD, and amyotrophic lateral sclerosis (ALS; Hanson et al., 2012; Jo et al., 2020; Klim et al., 2021).