Genome-wide histone acetylation analysis in PD patients revealed increased acetylation at multiple histone sites (H2B, H3, and H4), with the most notable change observed for H3K27, strongly suggesting that abnormal histone modification and altered transcriptional regulation are involved in the pathophysiology of PD (Toker et al., 2021). The gene discussed is H2BC21; the disease is Parkinson disease.