PPARGC1A and Parkinson disease: PGC-1α is a transcriptional coactivator that positively regulates expression of several genes required for mitochondrial biogenesis and antioxidant response; the level of PGC-1α is decreased in PD patients (Jo et al., 2021); therefore, PGC-1α has become a promising therapeutic target for neuroprotection in PD interventions.