Less common causes of FH are a few variants of the gene encoding for apolipoprotein B (APOB) that interfere with the binding of LDL to its receptor or gain-of-function variants in the gene encoding for proprotein convertase subtilisin/Kexin type 9 (PCSK9), a protein involved in the LDLR degradation (Nordestgaard et al., 2013). The gene discussed is PCSK9; the disease is familial hyperaldosteronism.