These data can be found here: To investigate the 4.1N/EPB41L1 gene methylation and its relation to NSCLC patient prognosis, TCGA methylation data (https://cancergenome.nih.gov/) of the array features 450k CpG sites covering the 4.1N gene promoter region (TSS200 and TSS1500) were analyzed. Here, EPB41L1 is linked to non-small cell lung carcinoma.