However, methylation of the 4.1N/EPB41L1 gene might be an important mechanism for tumor formation in LUAD and LUSC because high 4.1N/EPB41L1 gene methylations were observed at stage I. Because the MethSurv tool (https://biit.cs.ut.ee/methsurv/) lacks LCLC data, the prognostic relevance of 4.1N/EPB41L1 hypermethylation in LCLC was unknown. The gene discussed is EPB41L1; the disease is neoplasm.