IFNG and bacterial meningitis: Again, at early time points no important changes are seen, but at late time points, a significant increase in the concentration was observed for all these cytokines, suggesting the activation of a Th1 and Th17 response starting around day 4. A strong Th1 response characterized by high levels of IFNg was also demonstrated in a murine model of bacterial meningitis by type 4 S.