Mutant proteins p25 and p29 are stripped of their membrane anchoring sequences, which will lead to relocation of the active CDK5 complex, resulting in aberrant activation of CDK5, which has been confirmed in many neurotoxic diseases, such as Alzheimer's disease, Parkinson's disease, cerebral ischemia, and neurodegenerative diseases [11–13]. Here, CDK5 is linked to brain ischemia.