IFNG and obesity due to melanocortin 4 receptor deficiency: While adipose tissue in individuals with a healthy weight predominately contains regulatory and suppressive cytokines including IL-4, IL-10, IL-13, and IL-33, adipose tissue in individuals who are obesity is associated inflammatory cytokines including IL-1β, IL-6, IL-12, IL-18, TNF-α, and IFN-γ (30–32).