In addition, SIRT1 attenuates development of hyperphosphatemia-related vascular calcification via inhibiting cell senescence and osteogenic phenotype switching of VSMCs and therefore activation of SIRT1 or restauration of Sirt1 expression could be a reasonable approach to reduce hyperphosphatemia-induced medial calcification in CKD patients (38). This evidence concerns the gene SIRT1 and chronic kidney disease.