These myeloid cell phenotypic changes may also be beneficial for maintaining metabolic health beyond adipose innervation remodeling—for example, Fc-gamma receptor (FcγR)-dependent phagocytosis, which we see upregulated in cold-stimulated CINCs (Figures 1E, F), is impaired in monocytes of type II diabetes patients with chronic hyperglycemia (38). Here, FCGR2A is linked to type 2 diabetes mellitus.