Hyperglycemia was associated with an increased risk of frailty in two cross-sectional studies (Blaum et al., 2009; Lee et al., 2020) and three longitudinal studies (Graciani et al., 2016; Kalyani et al., 2012; Zaslavsky et al., 2016) after adjusting for sex, education, body mass index (BMI), interleukin-6, and chronic comorbidities such as diabetes mellitus, osteoarthritis, coronary heart disease, stroke, chronic pulmonary disease, and renal diseases, irrespective of participant’s diabetic status. This evidence concerns the gene IL6 and osteoarthritis.