Hyperglycemia was associated with an increased risk of frailty in two cross-sectional studies (Blaum et al., 2009; Lee et al., 2020) and three longitudinal studies (Graciani et al., 2016; Kalyani et al., 2012; Zaslavsky et al., 2016) after adjusting for sex, education, body mass index (BMI), interleukin-6, and chronic comorbidities such as diabetes mellitus, osteoarthritis, coronary heart disease, stroke, chronic pulmonary disease, and renal diseases, irrespective of participant’s diabetic status. The gene discussed is IL6; the disease is Hyperglycemia.