Higher numbers of intratumoral regulatory T lymphocytes and programmed cell death protein 1 (PD-1–), lymphocyte-activation gene 3 (LAG3–), and T cell immunoglobulin and mucin domain-containing protein 3 (TIM3)–expressing tumor-infiltrating (CD4+) T lymphocytes have been associated with poor prognosis (17), although TIM3 expression alone has been reported to be an independent prognostic factor for longer survival (11). This evidence concerns the gene PDCD1 and neoplasm.