LAG3 and neoplasm: Higher numbers of intratumoral regulatory T lymphocytes and programmed cell death protein 1 (PD-1–), lymphocyte-activation gene 3 (LAG3–), and T cell immunoglobulin and mucin domain-containing protein 3 (TIM3)–expressing tumor-infiltrating (CD4+) T lymphocytes have been associated with poor prognosis (17), although TIM3 expression alone has been reported to be an independent prognostic factor for longer survival (11).