Further, higher CD163/CD8 and CD163/CD20 ratios have been shown to be independent prognostic factors of shorter survival in MPM (9), and patients with MPM with higher M2/total tumor-associated macrophage (TAM) ratio have been shown to be more prone to develop local tumor outgrowth compared with those with low M2/TAM ratio (28). Here, CD8A is linked to neoplasm.