Using CD3 and EGFR targeting antibodies with a different approach, the synthetic multivalent antibodies retargeted exosomes (SMART-Exos) nanomedicine platform was designed to redirect and activate cytotoxic T cells toward TNBC cells, inducing a potent anti-tumor immune response in a human TNBC xenograft mouse model (42). The gene discussed is EGFR; the disease is neoplasm.