Folate receptor alpha (FRα) is a glycosylphosphatidylinositol (GPI)-linked membrane protein that binds to and mediates the intracellular transport of folate, and FRα is overexpressed in cancers of epithelial origin including lung, colorectal, ovarian, and breast tumors, correlated to a poor prognosis. The gene discussed is FOLR1; the disease is breast neoplasm.