Furthermore, AXL-CAR-T cells may be able to overcome the immunosuppressive TME by inhibiting the release of suppressive chemokines and cytokines from tumor-associated microphage (TAM) and by causing myeloid-derived suppressor cell (MDSC) depletion from the TME, fundamentally altering the TME to a proinflammatory state (98–100). The gene discussed is AXL; the disease is neoplasm.