Similar to CheckMate 153, the Japanese phase III SAVE study (130)recruits NSCLCs with good response and no serious side effects after 1-year anti-PD-1/L1 therapy, the French DICIPLE study (131) recruits patients with stage IV NSCLC without progression after 6-months combination therapy of nivolumab plus ipilimumab, and the UK phase III DANTE study (132) recruits progression-free melanomas after 1-year anti-PD-1 therapy. The gene discussed is PDCD1; the disease is melanoma.