The multivariable analyses showed that aberrant p53 expression (OR, 12.661; 95%CI, 3.006–57.364), MSI (OR, 4.414; 95%CI, 1.331–15.326), and CA125 ≥35 (OR, 5.309; 95%CI, 1.563–20.013) were independent predictors of lymph node metastasis. Here, MUC16 is linked to metastatic malignant neoplasm in the lymph nodes.