IL6 and central nervous system cancer: Aside from some known pathways supposedly involving gp96, such as the unfolded protein response, epithelial-mesenchymal transition, angiogenesis, and apoptosis [11, 13], the most intriguing finding was that inflammation-related pathways, such as the IFN-α response, the IL6-JAK-STAT6 signaling pathway, and the IFN-γ response, were highly enriched in gp96-related DEGs (Figures 6(a) and 6(b), Supplemental Figures 7(c) and 7(d)), suggesting an important role of gp96 in regulating the inflammatory response in glioma.