However, we also observed that gp96 expression was highly correlated with some well-known protumor pathways, such as epithelial-mesenchymal transition, the G2/M checkpoint and angiogenesis (Figure 6(a)), implying other mechanisms that could be involved in the gp96-mediated promotion of glioma development, thereby warranting further investigation on the exact mechanisms. The gene discussed is HSP90B1; the disease is central nervous system cancer.