Moreover, both 5 and 10 μM neferine memorably increased the relative protein expression of E-cadherin, while notably declined the relative protein level of N-cadherin and vimentin of IHH-4 and CAL-62 cells, suggesting that neferine overtly hindered the EMT of thyroid cancer cells (Figures 2(c)–2(e)). This evidence concerns the gene CDH2 and thyroid cancer.