The results of the pan-cancer analysis showed that the expression of most immunomodulatory factors and immune checkpoint mRNA was positively correlated with LINC01615; however, the LINC01615 expression in HNSCC was negatively correlated with immune-stimulator genes, such as TMIGD2, CD40LG, and TNFRSF13B,. The gene discussed is TMIGD2; the disease is cancer.