The results of the pan-cancer analysis showed that the expression of most immunomodulatory factors and the immune checkpoint mRNA were positively correlated with LINC01615; however, the LINC01615 expression in HNSCC was negatively correlated with immune-stimulator genes, such as TMIGD2, CD40LG, and TNFRSF13B. The gene discussed is TNFRSF13B; the disease is head and neck squamous cell carcinoma.