CRNDE and familial pancreatic carcinoma: For example, Fu et al. [20] verified that the expression level of lncRNA HOTTIP was aberrantly upregulated in pancreatic cancer and affected the function of tumor stem cells through HOXA9; Wang et al. [21] reported that lncRNA CRNDE regulated the proliferation and metastasis abilities of pancreatic cancer cell by competing endogenous RNA (ceRNA) network sponging miR-384.