A summary of the area we have covered; 1) discovery of CXCR3 and its ligands, 2) evolution of CXCR3, 3) structural and functional aspects of the receptor and its subsequent signaling mechanisms, 4) expression pattern of CXCR3 in development and diseases, and 5) its role in wound healing and a wide variety of neurological and cardiovascular disorders. The gene discussed is CXCR3; the disease is cardiovascular disorder.