LncRNA MEG3 is highly expressed in CD4+ T cells of ITP patients, resulting in an imbalance in the Treg/Th17 ratio through sponging miR-125a-5p; this then promotes Th17-cell differentiation and causes an immune imbalance in ITP patients (Li et al., 2016). This evidence concerns the gene CD4 and autoimmune thrombocytopenic purpura.