In ozone-induced exacerbation of asthma, PVT1 activates the asthma-related phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway by inhibiting miR-15a-5p, leading to a decrease in Th1/Th2 ratio, thereby promoting the progression of asthma. The gene discussed is MTOR; the disease is asthma.