In the current study, we found that BRD4 shRNA induce growth‐inhibition in KU812 and K562 cells and that the BRD4‐targeting drugs JQ1 and OTX‐015 suppress proliferation of KU812 and primary CML cells. The gene discussed is BRD4; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.