The latter leads to an imbalance of excitation and inhibition in the developing brain, as can be found, for example, in disorders like Fragile X-syndrome, CDKL5 encephalopathy, and tuberous sclerosis complex (TSC), neuroligin mutations, interneuronopathies (e.g., ARX) and NRP2 mutations [24]. This evidence concerns the gene CDKL5 and tuberous sclerosis.