The anti-immunoglobulin-like cell adhesion molecule (anti-IgLON5-IgG) disease represents an atypical form of AIE, manifesting mainly as a neurodegenerative disorder with sleep disturbances, bulbar dysfunction, progressive supranuclear palsy (PSP), CI and peripheral nervous system alterations [124]. The gene discussed is IGLON5; the disease is supranuclear palsy, progressive, 1.