Interestingly, the H2O2 level was further enhanced as a result of the CAT-suppressive feature of the 3-AT molecule and GSH-depleting behavior of PHMZCO-AT, boosting the production of •OH for effective oxidative damage, and a superior tumor inhibition rate (81.9%) was achieved on 4 T1 tumor xenografts. Here, CAT is linked to neoplasm.