FTO and leukemia: For example, R-2-hydroxyglutaric acid (R-2HG) stimulates overall m6A methylation modifications of RNA in R-2HG-sensitive leukemia cells by inhibiting FTO activity, which, in turn, reduces the stability of MYC/CEBPA transcripts, thereby suppressing leukemia cell proliferation/viability and promoting cell cycle arrest (G2/M) and apoptosis [237].