Expression of fatty acid binding protein-5 (FABP5) is regulated by FTO in liver tissues [83], and it is proposed that FABP5 could enhance HIF-1α activity by disrupting FIH/HIF-1α interactions when promoting HIF-1α synthesis, thereby activating the FABP5/HIF-1α axis to support lipid accumulation in the liver and facilitate HCC proliferation [84]. This evidence concerns the gene FTO and hepatocellular carcinoma.