YTHDF1 and neoplasm: Interestingly, lung cancer cells adapt to the hypoxic microenvironment and mediate cisplatin resistance through the Keap1-Nrf2-AKR1C1 signaling axis by suppressing YTHDF1 expression, meanwhile, YTHDF1 inhibition regulates the translation of CDK2, CDK4 and cytokine D1, further promoting distant tumor metastasis [31].