Tumor-associated macrophages (TAMs) are at the core of the immunosuppressive cell and cytokine networks that play a critical role in tumor immune evasion through mechanisms associated with m6A modifications, such as promotion of TAM aggregation and immunosuppressive functions of ALKBH5 [148] and involvement of FTO in macrophage M2 polarization via the NF-κB pathway [32, 142]. This evidence concerns the gene NFKB1 and neoplasm.