For example, knockdown of the lncRNA LINRIS in colorectal cancer blocks K139 ubiquitination of IGF2BP2 (a m6A reader), preventing its degradation by the autophagic lysosomal pathway and ultimately, attenuating the downstream pathways of IGF2BP2, such as MYC-mediated glycolysis in tumor cells [228]. Here, IGF2BP2 is linked to neoplasm.