METTL3 and colorectal cancer: For example, 3-deazaadenosine inhibits METTL3/METTL14 [277], CA4 (carbonic anhydrase member) induces WTAP degradation and suppresses colorectal cancer proliferation [278], and R-2-hydroxyglutarate (R-2HG) delays leukemia progression via inhibition of FTO [237].