For instance, in hypoxic TME, CAFs alter their exosome content and increase exosome release through metabolic reprogramming [175], CAF-derived exosomes have been shown to inhibit the sensitivity of colorectal cancer cells to 5-fluorouracil and promote metastasis via the METTL3/miR-181d-5p axis [176]. Here, METTL3 is linked to colorectal cancer.