For instance, upregulation of hepatitis B virus X-interacting protein (HBXIP) positively promotes expression of the m6A methylase METTL3, resulting in enhanced HIF-1α expression and maintenance of high levels of glycolysis, thus promoting malignant proliferation of hepatocellular carcinoma (HCC) [33]. The gene discussed is HIF1A; the disease is hepatocellular carcinoma.