Mechanistically, hypoxia-mediated HIF-1α induces expression of the m6A methylation reader, YTHDF1, and promotes translation of autophagy-related genes, ATG2A and ATG14, in a m6A methylation-dependent manner, resulting in autophagy and tumorigenesis of HCC [81]. The gene discussed is YTHDF1; the disease is hepatocellular carcinoma.